Review of Capsimax Trial
In a clinical study conducted at the University of Oklahoma, Capsiplex was given to 25 volunteers between the ages of 10-30. The clinical study design was a double-blind, randomized placebo controlled cross over study.
All volunteers had their vital signs, height and blood samples taken. Half the group took Capsiplex one day and half the group took a placebo, one week later the group swapped with some taking the placebo and some taking Capsiplex.
So this trial may have to be conducted again to be truly a double-blind placebo trial, because the subjects were aware of whether they were taking a placebo or not, and they swapped from being on placebo to being Capsiplex mid trial.
The testing criteria for; method for perception testing energy expenditure and times that vital signs, BP, ventilation and energy expenditure were taken and the methodology behind this analysis of this were not fully stated. The subjects were monitored during four periods as follows:
Energy expenditure (Kcal/day), oxygen consumption (ml/kg/min), ventilation (L/min), rating of perceived exertion, heart rate and systolic and diastolic blood pressure (mmHg) were taken on second and third visits.
The Results:
Upon baseline adjustment, statistical analysis indicated that when the subjects took Capsiplex™, they burned 3-times more calories before exercise 3% more calories during, and 12 times more calories for up to one hour after exercise compared to when they took placebo.
This resulted in an average cumulative total of 278 more calories burned before, during and after exercise compared to placebo. The product was well tolerated and energy expenditure rose, as did greater oxygen intake during the exercise period.
The volunteers reported that they did not perceive that they were exerting themselves more, despite expending more energy than the placebo groups.
The Results:
Although this study is promising we cannot state that is would stand up to rigorous scientific trial design and validity.
More studies should be carried out on Capsiplex to validate the results. At this stage we do not use this trial to endorse the efficacy of this product, but it demonstrates that more studies would be worthwhile and potentially promising.
We are aware that many people research online these days; with that in mind we have provided links to published papers on some of the ingredients in our product.
* Capsiplex uses these ingredients in combination and the mg dose and different clinical trial circumstances differ. We are not providing this data as a direct proof of efficacy for our product because that would require rigorous scientific trials on the exact combination of ingredients we use. Capsiplex has had a trial conducted on it which you can view below.
The human body needs energy to power muscles and to fuel the millions of chemical and biological reactions which take place throughout our system every day. This energy comes from the food we consume in our diet.
Food consists mainly of water and three types of nutrient - protein, dietary fats and carbohydrate - which are found in varying proportions in most foods. These nutrients are broken down, digested and absorbed by the body in the gastrointestinal tract, running from the mouth to the anus.
Each of these macronutrients is processed and absorbed by the digestive system in different ways.
Simple carbs like glucose are absorbed into the blood stream very quickly. All cells in your body use glucose for energy so the body converts all carbohydrate foods into this form of energy, which is why runners sometimes take glucose drinks to keep their energy up, because it is absorbed for energy so quickly by the body.
Carbohydrate foods include sugars such as: Fructose (from fruit), Glucose (sports drinks), Lactose (from milk products), and Maltose (often used in cereals).
Carbohydrate Starches also get converted into glucose by the body and these include: potatoes, rice, pasta, couscous, noodles, Cereals, breads, pulses, lentils, beans and peas.
The term Low Glycemic Index food basically means the foods that take the longest to be converted into glucose by the body. Low glycemic index foods are considered beneficial for health because they keep energy levels balanced.
Once these foods have been converted into glucose, it inters the bloodstream and the blood-glucose level rises.
The body doesn’t want to give its self too much energy so the pancreas secretes insulin into the blood to “mop up” any excess glucose. This excess glucose (pure energy) has to be stored, so it is turned into a substance called glycogen (packaged stored glucose).
The body stores its glycogen in the liver and muscles and will convert it back into glucose for energy when, it needs more energy.
However here is the glitch! When the liver and muscle glycogen stores are full (add they can be full pretty quickly!), the body has no room left for storage in these compartments.
It must find another way of storing it’s excess energy so it converts the glucose into fat and stores it on your bottom, your thighs, your tummy and your upper arms, if those places are full it will start storing it all over the body, you get the picture!
This is why so many diet and weight loss books, websites, health professionals and treatments include tips such as cutting down on sugar and carbs like potatoes and white bread, crisps and pastries.
The body uses fat from our food as a back-up form of energy if blood glucose supplies run out (about 4-6 hours without foods). It also uses fat to provide insulation under our skin, to protect our organs and bones from physical damage, fat also surrounds our nerve fibre to protect it and help transmit messages.
Fat is actually used in every cell in our body to help transport nutrients and metabolites across our cell membranes. It also uses fat as a starting material to build many other substances in our body like hormones and immune cells. It is also need for anything that is fat soluble for example vitamins like, vitamin, A, D, E, K.
It also helps foods stay in our stomachs for longer, because the stomach is mostly watery and fat takes a while to be broken down. So our body does need fat to stay healthy and functioning.
Our bodies have not evolved as fast as technology and the modern world has, so our bodies still have a mechanism for storing excess fat in case we need it during times of starvation. This excess fat from that the body does not need is stored in the form of adipose tissue on our thighs, our bottoms, our tummies etc.
Bile is a bit like the body’s Fairy liquid, it has properties that can break up fat.
Dietary fat is broken down into Lipids called fatty acids and glycerol. Glycerol can be converted into glucose for energy, but only a very small amount of fat is made up of parts that can be converted into glycerol. Fatty acids also get converted into another type of lipid called triglycerides and travel around the body to where they are needed.
The liver uses some of these triglycerides to convert fat into cholesterol for making hormones and cell membranes.
Cholesterol has to be transported from the liver to cells in the body by carriers, called Low density Lipoprotients (LDLs) which are sometimes referred to as “bad cholesterol". This is because they can take too much cholesterol to the body and it can end up lining the arteries and causing blockages, which lead to conditions like high blood pressure.
Cholesterol is collected from our tissues and returned to the liver by High density lipoproteins (HDL’s), which is sometimes referred to as “good cholesterol".
Unfortunately most people in the UK eat too much saturated fat. Saturated fat (solid at room temperature) is more difficult for the body to breakdown than unsaturated fat (liquid at room temperature).
Because saturated fat is more difficult for the body to breakdown it can end up clogging our arteries which is bad for our health. Foods that are high in saturated fat include: meats (particularly pork and red meat), eggs, cheese and butter.
Many people recommend low fat diets for losing weight, but actually there are some fats out there that are essential for body function such as;
High fat fish such as;
These are great sources of natural omega-3-polyunsatured fats, which are very good for you.
Even saturated fats from meat and butter have some value, particularly organic. The bottom line is we do need fat to for our bodies to function, but choose your fats carefully.
The really bad for you fats are chemically processed Trans-fats, like hydrogenated oils which are industrially produced, chemically altered oils that are present in many processed foods.
Other refined oils like canola, are not hydrogenated but go through high temperature, high pressure solvent extraction processes. The more a food is processed industrially the more likely it is to have lost its value.
The body will become confused about how to break it down and may end up sending it for storage, and we know where that goes!
Foods that are deep fried in these types of industrial saturated fats include;
If people do not get enough good fat in their diet they tend to put on weight, this is because many processed fats are difficult for the body to breakdown and are part of foods that can be high in sugar, like processed biscuits, cakes, puddings and pastries.
Other signs of lack of good healthy fat intake are dry skin, low body weight, feeling cold, and poor hair and nail growth and in extreme cases loss of menstruation can occur. Essential fatty acids are also reported to be good for brain function.
Blood glucose:
In animal and human research, capsaicin was shown in some cases to reduce blood glucose (Tolan et al, 2004, Chaiyata et al 2003 & 2009), these studies have been conducted on Capsicum frutescens, which is a different species of chilli to the one we use in Capsiplex, but these two species share a lot of the same active chemicals.
Lipids:
In rats, Capsicum was shown to reduce cholesterol levels (Gupta et al 2002). In humans, the carotenoid capsanthin, a constituent of Capsicum anuum, resulted in increases in plasma HDL cholesterol and had no effect on plasma total cholesterol and triglyceride concentrations (Aizawa et al 2009).
Capsaicin resulted in reduced LDL cholesterol and increased HDL cholesterol and triglyceride levels in rats (Lee et al 2003).
Weight Loss: Human studies
Chili was shown in this study to reduce high insulin levels after meals in one study (Ahuja et al, 2006). A dietary Capsicum ingestion led to increases in carbohydrate oxidation both at rest and during exercise, this may mean further studies into the role of capsicum and its role in the breakdown of carbohydrates in the body might be worthwhile (Lim et al, 1997).
Other studies have found that capsaicin or other constituents of Capsicum were found to increase energy expenditure during exercise and play a role in the breakdown of fat (Inoue et al 2007, Lejeune et al, 2003, Shin et al, 2007).
A study which included cayenne in the meals of overweight individuals showed a decrease in hunger and an increase in feeling full, suggesting a role for capsicum in appetite suppression (Reinbach et al, 1999).
An appetite and energy intake suppressive effect of cayenne has been shown in Japanese females and Caucasian males (Yoshioka et al et al 1999). In Thai women, 5g of fresh chili pepper was found to increase the metabolic rate, indicated that it perhaps aids in weight loss (Chaiyata et al 1997).
In animal studies:
The various other constituents other than were also for weight loss effects in humans and non- pungent capsinoids were found to have a positive role. (Snitker et al 2009)
Although the mechanism of action of capsaicin in weight loss is not clear, some evidence from animal studies suggests that vanilloid receptors may play a role in regulation of body weight (Melnyk et al, 1995, Zhang et al, 2007).
Also, in animal study, capsaicin induced thermogenesis by a mechanism likely involving beta-adrenergic stimulation (Osaka et al, 2002). Other potential mechanisms include stopping the release of the enzyme that converts fats to adipose tissue (kang et al, 2007), activation of glycolytic enzymes (Han et al, 2009), and increase in thermogenesis (Hachiya et al, 2007).
As you can see, Capsiplex is well proven and will work for you. In literally weeks from now you will be stood in front of the mirror with a huge smile on your face as your weight loss dreams finally become reality.
All that’s left is to click here to order your supply of Capsiplex while we have the stock.
*These are not studies conducted on our product and we do not make health claims based on of the evidence found in these studies. They are for interest reference only. Food supplements are to be taken in addition to normal nutrition. Always consult your doctor, healthcare provider or pharmacist for more advice.
References:
Kang, J. H., Kim, C. S., Han, I. S., Kawada, T., and Yu, R. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Lett. 9-18-2007;581(23):4389-4396.
Osaka, T., Kobayashi, A., and Inoue, S. Vago-sympathoadrenal reflex in thermogenesis induced by osmotic stimulation of the intestines in the rat. J.Physiol 4-15-2002;540(Pt 2):665-671.
Reinbach, H. C., Smeets, A., Martinussen, T., Moller, P., and Westerterp-Plantenga, M. S. Effects of capsaicin, green tea and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. Clin Nutr. 2009;28(3):260-265.
Yoshioka, M., St Pierre, S., Drapeau, V., Dionne, I., Doucet, E., Suzuki, M., and Tremblay, A. Effects of red pepper on appetite and energy intake. Br.J.Nutr. 1999;82(2):115-123.
Snitker, S., Fujishima, Y., Shen, H., Ott, S., Pi-Sunyer, X., Furuhata, Y., Sato, H., and Takahashi, M. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am.J.Clin.Nutr. 2009;89(1):45-50.
Melnyk, A. and Himms-Hagen, J. Resistance to aging-associated obesity in capsaicin-desensitized rats one year after treatment. Obes.Res 1995;3(4):337-344.
Zhang, L. L., Yan, Liu D., Ma, L. Q., Luo, Z. D., Cao, T. B., Zhong, J., Yan, Z. C., Wang, L. J., Zhao, Z. G., Zhu, S. J., Schrader, M., Thilo, F., Zhu, Z. M., and Tepel, M. Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ.Res 4-13-2007;100(7):1063-1070.
Han, J. and Isoda, H. Capsaicin induced the upregulation of transcriptional and translational expression of glycolytic enzymes related to energy metabolism in human intestinal epithelial cells. J Agric.Food Chem. 12-9-2009;57(23):11148-11153.
Hachiya, S., Kawabata, F., Ohnuki, K., Inoue, N., Yoneda, H., Yazawa, S., and Fushiki, T. Effects of CH-19 Sweet, a non-pungent cultivar of red pepper, on sympathetic nervous activity, body temperature, heart rate, and blood pressure in humans. Biosci.Biotechnol.Biochem. 2007;71(3):671-676.
Ahuja, K. D., Robertson, I. K., Geraghty, D. P., and Ball, M. J. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am.J.Clin.Nutr. 2006;84(1):63-69.
Gupta, R. S., Dixit, V. P., and Dobhal, M. P. Hypocholesterolaemic effect of the oleoresin of Capsicum annum L. in gerbils (Meriones hurrianae Jerdon). Phytother.Res. 2002;16(3):273-275.
Aizawa, K. and Inakuma, T. Dietary capsanthin, the main carotenoid in paprika (Capsicum annuum), alters plasma high-density lipoprotein-cholesterol levels and hepatic gene expression in rats. Br.J Nutr. 2009;102(12):1760-1766.
Lee, C. Y., Kim, M., Yoon, S. W., and Lee, C. H. Short-term control of capsaicin on blood and oxidative stress of rats in vivo. Phytother.Res. 2003;17(5):454-458.
Tolan, I., Ragoobirsingh, D., and Morrison, E. Y. Isolation and purification of the hypoglycaemic principle present in Capsicum frutescens. Phytother.Res. 2004;18(1):95-96.
Chaiyata, P., Puttadechakum, S., and Komindr, S. Effect of chili pepper (Capsicum frutescens) ingestion on plasma glucose response and metabolic rate in Thai women. J.Med.Assoc.Thai. 2003;86(9):854-860.
Chaiyasit, K., Khovidhunkit, W., and Wittayalertpanya, S. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med.Assoc.Thai. 2009;92(1):108-113.
Ahuja, K. D., Robertson, I. K., Geraghty, D. P., and Ball, M. J. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am.J.Clin.Nutr. 2006;84(1):63-69.
Lim, K., Yoshioka, M., Kikuzato, S., Kiyonaga, A., Tanaka, H., Shindo, M., and Suzuki, M. Dietary red pepper ingestion increases carbohydrate oxidation at rest and during exercise in runners. Med.Sci.Sports Exerc. 1997;29(3):355-361.
Shin, K. O. and Moritani, T. Alterations of autonomic nervous activity and energy metabolism by capsaicin ingestion during aerobic exercise in healthy men. J.Nutr.Sci.Vitaminol.(Tokyo) 2007;53(2):124-132.
Inoue, N., Matsunaga, Y., Satoh, H., and Takahashi, M. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Biosci.Biotechnol.Biochem. 2007;71(2):380-389.
Lejeune, M. P., Kovacs, E. M., and Westerterp-Plantenga, M. S. Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br.J.Nutr. 2003;90(3):651-659.